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Indications and Dosage
Oral
Allergic conditions Adult: 8 mg, as necessary, up to tid.
Child: ≥12 yr Same as adult dose. |
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Renal Impairment
Severe: Contraindicated.
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Administration
May be taken with or without food.
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Contraindications
Severe renal impairment.
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Special Precautions
Patient w/ porphyria, epilepsy. Renal impairment. Elderly. Pregnancy and lactation.
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Adverse Reactions
Anticholinergic effects, GI disturbance, headache, psychomotor impairment, somnolence, dry mouth, rash, blurred vision, urinary retention. Rarely, dizziness, dyspnoea, angioedema.
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PO: Z (Adverse pregnancy outcomes (e.g. spontaneous abortions, intrauterine death) have been reported. Should not be used unless benefits outweigh risks.)
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Patient Counseling Information
This drug may cause dizziness and somnolence, if affected, do not drive or operate machinery.
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Drug Interactions
May produce additional mental depression w/ CNS depressants.
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Food Interaction
May produce additional mental depression w/ alcohol.
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Action
Description:
Mechanism of Action: Acrivastine, an alkylamine, is a second generation antihistamine structurally related to triprolidine. It is a competitive antagonist of H1-receptors but lacks anticholinergic effects. Onset: 15 min. Pharmacokinetics: Absorption: Rapidly absorbed from the GI tract. Time to peak plasma concentration: Approx 1.5 hr. Distribution: Volume of distribution: Approx 0.5-0.8 L/kg. Plasma protein binding: Approx 50%, mainly to albumin. Metabolism: Minimally metabolised in the liver into its active metabolite, propionic acid. Excretion: Via urine (84%) and faeces (13%). Elimination half-life: Approx 2-4 hr. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Acrivastine, CID=5284514, https://pubchem.ncbi.nlm.nih.gov/compound/Acrivastine (accessed on Jan. 20, 2020) |
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Storage
Store at or below 30°C.
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MIMS Class
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ATC Classification
R06AX18 - acrivastine ; Belongs to the class of other antihistamines for systemic use.
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References
Anon. Acrivastine and Pseudoephedrine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 09/08/2016. Buckingham R (ed). Acrivastine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/08/2016. Joint Formulary Committee. Acrivastine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/08/2016. McEvoy GK, Snow EK, Miller J et al (eds). Acrivastine. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 09/08/2016.
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