Alimemazine

Oral
Premedication in surgery

Oral
Pruritic skin disorders, Urticaria

Contraindicated.

Contraindicated.

May be taken with or without food.

Epilepsy, parkinsonism, hypothyroidism, phaechromocytoma, myasthenia gravis, prostatic hypertrophy, history of narrow angle glaucoma. Renal and hepatic impairment. Childn <2 yr. Lactation.

Patient w/ volume depletion, CV disease, chronic constipation, pyloroduodenal obstruction, urinary retention, history of seizure. Childn and elderly. Pregnancy.

Nasal stuffiness, dry mouth, insomnia, agitation, convulsion; jaundice; hypotension, pallor; AV block, ventricular tachycardia and fibrillation; ECG changes; mild leucopenia, unexplained fever/infection; acute dystonia/dyskinesia, akathisia, parkinsonism, tremor, rigidity, akinesia, tardive dyskinesia; skin rashes, photosensitivity, ocular changes, metallic greyish-mauve colouration of skin; hyperprolactinaemia (i.e. galactorrhoea, gynaecomastia, amenorrhoea, impotence); neuroleptic malignant syndrome (i.e. hyperthermia, autonomic dysfunction, altered consciousness); paradoxical excitement. Rarely, agranulocytosis, contact skin sensitisation.

Avoid alcohol intake and exposure to sunlight. This drug may cause drowsiness, if affected, do not drive or operate machinery.

Monitor vital signs and mental status.

Symptoms: Drowsiness, loss of consciousness, hypotension, tachycardia, ECG changes, ventricular arrhythmia, hypothermia, severe extrapyramidal dyskinesia, generalised vasodilation, circulatory collapse, neuroleptic malignant syndrome (NMS) (i.e. hyperthermia, muscle rigidity, altered mental status, autonomic instability). Management: Supportive treatment. Employ gastric lavage or activated charcoal. Pronounced CNS depression may require airway maintenance or assisted respiration (in extreme cases). Treat generalised vasodilation w/ warmed IV infusion fluids and by raising patient’s legs. Treat severe dystonic reactions w/ 5-10 mg of procyclidine or 20-40 mg of orphenadrine via IV/IM inj. Treat convulsions w/ IV diazepam. Treat NMS by cooling or w/ dantrolene Na.

Intensified sedative effect w/ anxiolytics, hypnotics, opiates, barbiturates, and other sedatives. Interfered absorption w/ antacids, antiparkinson agents, and lithium. May exaggerate the hypotensive effects of antihypertensive drugs esp α-adrenoreceptor blockers. May increase side effects of antimuscarinics. May oppose actions of amphetamine, levodopa, clonidine, guanethidine, and epinephrine. May reduce the response to hypoglycaemic agents.

Absorption is delayed by food. Intensified sedative effect w/ alcohol.

Description:
Mechanism of Action: Alimemazine, a phenothiazine derivative, is an antihistamine w/ marked sedative and antiemetic effects. Additionally, it has antispasmodic, antiserotonin, and weak antimuscarinic properties.
Pharmacokinetics:
Absorption: Delayed by food. Bioavailability: <70%.
Distribution: Plasma protein binding: >90%.

Source: National Center for Biotechnology Information. PubChem Database. Trimeprazine, CID=5574, https://pubchem.ncbi.nlm.nih.gov/compound/Trimeprazine (accessed on Jan. 20, 2020)

Store below 25°C. Protect from light.

Antihistamines & Antiallergics

R06AD01 - alimemazine ; Belongs to the class of phenothiazine derivatives used as systemic antihistamines.

Anon. Trimeprazine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 19/08/2016.

Buckingham R (ed). Alimemazine Tartrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 19/08/2016.

Joint Formulary Committee. Alimemazine Tartrate (Trimeprazine Tartrate). British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 19/08/2016.