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Indications and Dosage
Oral
Threatened miscarriage Adult: 5 mg tid for 5-7 days, treatment may be prolonged if necessary. Gradually reduce dosage if symptoms disappear. Oral Recurrent miscarriage Adult: 5-10 mg daily as soon as pregnancy is confirmed. Continue treatment for at least 1 month after the critical period. Oral Premature labour Adult: For threatened premature labour: Individualise dosage. Max: 40mg daily.
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Hepatic Impairment
Contraindicated.
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Administration
May be taken with or without food. May be taken w/ meals if GI upset occurs.
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Contraindications
Hypersensitivity. Hepatic impairment.
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Special Precautions
Patient with diabetes. Pregnancy.
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Adverse Reactions
Significant: Visual disturbances, proptosis or diplopia, vascular retinal ulcer; migraine.
Gastrointestinal disorders: Nausea, vomiting. |
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Action
Description:
Mechanism of Action: Allylestrenol is a synthetic progestogen structurally related to progesterone. It exhibits trophoblastic, placentotrophic, and β2-adrenergic activity with no androgenic action. Allylestrenol stimulates the hormonal effects of existing syncytiotrophoblast which are necessary for progesterone production. The pregnancy-maintaining effect is due to the stimulation of the placental function, and the stimulation of β2-adrenergic receptors prevents uterine contractility. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 235905, Allylestrenol. https://pubchem.ncbi.nlm.nih.gov/compound/Allylestrenol. Accessed Aug. 25, 2020. |
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ATC Classification
G03DC01 - allylestrenol ; Belongs to the class of estren derivative progestogens used in progestogenic hormone preparations.
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References
Malhotra N, Garg R, Malhotra N et al. Oral Allylestrenol: A Pregnancy-Supporting Progestogen. J South Asian Feder Obst Gynae. 2017;9(4):297-303. doi: 10.5005/jp-journals-10006-1517. Accessed 30/06/2020 Alyrenol (Gracia Pharmindo). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 30/06/2020. Buckingham R (ed). Allylestrenol. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 30/06/2020. Pregnabion (Tunggal Idaman Abdi). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 30/06/2020. Pregnolin (Dexa Medica). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 30/06/2020. Pregtenol (Fahrenheit). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 30/06/2020.
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