Amadiab

Glimepiride

Type 2 diabetes inadequately controlled by diet, physical exercise & wt reduction alone.

1-8 mg daily. Initial dose & dose titration: 1 mg once daily. Daily dose may be increased at intervals of 1-2 wk, & carried out stepwise as follows: 1 mg-2 mg-3 mg-4 mg-6 mg, & in exceptional cases, 8 mg.

Should be taken with food: Take immediately before the 1st main meal of the day. Do not skip meals.

Type 1 DM, diabetic ketoacidosis, diabetic precoma, coma; severe renal impairment & hepatic dysfunction. Pregnancy & lactation.

Regular monitoring of glucose levels in blood & urine. Milder or absent symptoms of hypoglycaemia eg, in patients w/ autonomic neuropathy or taking β-blockers, clonidine, reserpine, guanethidine or other sympatholytics. Temporary changeover to insulin in exceptional stress situations (trauma, surgery, febrile infections).

Hypoglycaemia, temporary visual impairment, GI disturbances, liver impairment. Rarely, thrombopenia, leucopenia & haemolytic anaemia; itching, urticaria, rashes.

Effects potentiated when used w/ insulin & other antidiabetics, ACE inhibitors, allopurinol, anabolic steroids & male sex hormones, chloramphenicol, coumarin derivatives, cyclophosphamide, disopyramide, fenfluramine, fenyramidol, fibrates, fluoxetine, guanethidine, ifosfamide, MAOIs, miconazole, p-aminosalicylic acid, pentoxifylline (high-dose parenteral), phenylbutazone, azapropazone, oxyphenbutazone, probenecid, quinolones, salicylates, sulfinpyrazone, sulfonamides, tetracyclines, tritoqualine, trofosfamide. Effects weakened when used w/ acetazolamide, barbiturates, corticosteroids, diazoxide, diuretics, epinephrine & other sympathomimetics, glucagon, laxatives (after protracted use), nicotinic acid (high dose), oestrogens & progestogens, phenothiazines, phenytoin, rifampicin, thyroid hormones. β-blockers decrease glucose tolerance.

Antidiabetic Agents

A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.

G