Bacterial meningitis, Septicaemia
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 8,000-14,000 mg daily or 150-200 mg/kg daily in divided doses 3-4 hourly. May give initial treatment via slow IV inj for at least 3 days and continued with deep IM inj. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Infants and children Usual dose range: 100-200 mg/kg daily in divided doses 3-4 hourly; may give initial treatment via IV for 3 days and continue with IM inj. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Infants and children Usual dose range: 100-200 mg/kg daily in divided doses 3-4 hourly; may give initial treatment via IV for 3 days and continue with IM inj. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Intramuscular, Intravenous
Endocarditis, Intra-abdominal infections, Peritonitis, Respiratory tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 4-6 hourly via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 25-50 mg/kg daily in divided doses 6 hourly; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 25-50 mg/kg daily in divided doses 6 hourly; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Intramuscular, Intravenous
Gastrointestinal infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 6 hourly via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 50-100 mg/kg daily in divided doses 6 hourly via slow IV inj or IV infusion, or via deep IM inj; >40 kg: Same as adult dose. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 50-100 mg/kg daily in divided doses 6 hourly via slow IV inj or IV infusion, or via deep IM inj; >40 kg: Same as adult dose. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Intramuscular, Intravenous
Urinary tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 4-6 hourly; via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 50-100 mg/kg daily in divided doses 6 hourly via slow IV inj or IV infusion, or via deep IM inj; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 50-100 mg/kg daily in divided doses 6 hourly via slow IV inj or IV infusion, or via deep IM inj; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Oral
Lower respiratory tract infections, Upper respiratory tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 250-1,000 mg 6 hourly. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Oral
Urinary tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. 500 mg 6 or 8 hourly. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Oral
Gastrointestinal infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. 500-750 mg tid to 4 times daily. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Oral
Gonorrhoea
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. In combination with probenecid: 2,000 mg as a single dose; repeated doses are recommended in females. Consideration must be given to local treatment guidelines.
Child: Treatment recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Treatment recommendations may vary among individual products and between countries (refer to specific product guidelines).
Oral
Paratyphoid fever, Typhoid fever
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. 1,000-2,000 mg 6 hourly. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).