UTI due to E. coli,P. mirabilis,Klebsiella spp. Skin & skin tissue infection due to Staph &/or Strep. Pharyngitis & tonsillitis due to Streptococcus pyogenes.
Dosage/Direction for Use
AdultsUncomplicated UTI 1-2 g daily in a single dose or 2 divided doses. Other UTI 2 g daily in 2 divided doses. Skin & skin tissue infections 1 g daily in a single dose or 2 divided doses. Pharyngitis, tonsillitis 1 g daily in a single dose or 2 divided doses for 10 days. ChildnUTI 30 mg/kg/day to be given in divided dose 12 hrly. Pharyngitis, tonsillitis, impetigo 30 mg/kg/day in a single dose or in divided dose 12 hrly. Skin & other soft tissue infections 30 mg/kg/day in divided dose 12 hrly. For treatment of β-hemolytic streptococcal infections, doses should be given for min 10 days. Childn <1 yr 25 mg/kg/day in divided doses 12 hrly for min 10 days.
Administration
May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Contraindications
Hypersensitivity.
Special Precautions
Patients w/ allergy to penicillin. Clostridium difficile-Associated Diarrhea (CDAD) has reported after cefadroxil used. Prolonged use may cause overgrowth of cefadroxil non-sensitive microorganisms. Treatment should be discontinued if seizure occurs. May impair the ability to drive or operate the machinery. Kidney disorders. Pregnancy, lactation.
May cause false +ve in Coomb's test. Bacteriostatic antibiotics eg, tetracycline, erythromycin, sulfonamide, chloramphenicol, aminoglycosides, polymyxin B, colistin, or high dose of loop diuretics, anticoagulants, antiplatelets. Probenecids, OCs, cholestyramine.
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