Anpiride

Glimepiride

Type 2 DM inadequately controlled by diet, physical exercise & wt reduction. May be used in combination w/ metformin or insulin.

1-8 mg daily. Initial dose & dose titration: 1 mg once daily, may be increased at intervals of 1-2 wk & stepwise as follows: 1 mg, 2 mg, 3 mg, 4 mg, 6 mg & in exceptional cases, 8 mg.

Should be taken with food: Take immediately before the 1st main meal of the day. Do not skip meals.

Type 1 DM, diabetic ketoacidosis, diabetic precoma, coma; severe renal impairment & hepatic dysfunction. Pregnancy & lactation.

Regular monitoring of glucose levels in blood & urine. Milder or absent symptoms of hypoglycaemia in patients w/ autonomic neuropathy or taking β-blockers, clonidine, reserpine, guanethidine & other sympatholytics. Temporary change over to insulin in exceptional stress situations eg, trauma, surgery, febrile inj.

Hypoglycaemia, temporary visual impairment, GI disturbances, liver impairment. Rarely, thrombocytopenia, leucopenia & haemolytic anaemia; itching, urticaria, rashes.

Potentiation of effects when used w/ insulin & other antidiabetics, ACE inhibitors, allopurinol, anabolic steroids & male sex hormones, chloramphenicol, coumarin derivatives, cyclophosphamide, disopyramide, fenfluramine, fenylramidol, fibrates, fluoxetine, guanethidine, ifosfamide, MAOIs, miconazole, p-amino salicylic acid, pentoxifylline, high dose quinolones, salicylates, sulfinpyrazones, sulfonamides, tetracyclines, tritoqualine, trofosfamide. Weakening of the blood glucose lowering effects when used w/ acetazoliamide, barbiturates, corticosteroids, diazoxide, diuretics, epinephrine & other sympathomimetics, glucagon, laxatives (other protracted use), nicotinic acid (high dose), oestrogens & progesterons, phenothiazines, phenytoin, rifampicin, thyroid hormones, β-blockers decrease glucose tolerance.

Antidiabetic Agents

A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.

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