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Indications and Dosage
Intravenous
Prophylaxis of thromboembolism associated with surgical and obstetric procedures, Thromboembolic disorders Adult: Dosing is individualised based on pre-therapy antithrombin (AT) level and clinical condition. Loading: Dose targeted to achieve 120% of normal AT level via infusion. Maintenance: Dose targeted to achieve 80-120% (approx 60% of initial loading dose) of normal AT level via infusion 24 hrly as needed.
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Reconstitution
Allow the vials to reach room temp prior to reconstitution. Add 10 or 20 mL of sterile water for inj (w/o preservatives) to the vial containing approx 500 or 1,000 IU, respectively. Gently swirl to avoid foam formation. Filter through sterile filter needle provided by the manufacturer prior to admin.
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Special Precautions
May carry a risk of transmitting infectious agents (e.g. viruses, Creutzfeldt Jakob disease agents). Pregnancy and lactation.
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Adverse Reactions
Flushing, headache, dizziness, chest tightness, nausea, dysgeusia, chills, abdominal cramps, shortness of breath, lightheadedness, hives, fever; inj site oozing and haematoma. Rarely, allergic reactions.
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IV/Parenteral: C (manufacturer specific), B (manufacturer specific)
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Monitoring Parameters
Monitor vital signs, cardiac and CNS status during and after therapy. Monitor AT level at baseline, 20 min (peak) and 12 hr post-infusion, and before the next infusion (trough). Measure peak and trough AT levels w/ each subsequent dose until desired levels achieved.
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Drug Interactions
May enhance anticoagulant effect and increase the risk of bleeding w/ heparin and other anticoagulants.
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Action
Description:
Mechanism of Action: Antithrombin III, an α2-globulin, is the major inhibitor of in vivo coagulation. It inactivates thrombin, plasmin, and activated coagulation factors IXa, Xa, XIa, and XIIa, preventing the conversion of fibrinogen to fibrin, thereby inhibiting thrombus formation. Additionally, it is the cofactor through which heparin exerts in effect. Pharmacokinetics: Distribution: Distributed into plasma (39%), extravascular space (49%), and vascular endothelial cells (11%). Metabolism: Metabolised (<5%) to low molecular wt breakdown products. Excretion: Via urine (as complex w/ thrombin or other proteinases). Terminal elimination half-life: Biphasic; 2.5-4.8 days. |
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Storage
Store below 25°C. Do not freeze.
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ATC Classification
B01AB02 - antithrombin III ; Belongs to the class of heparin group. Used in the treatment of thrombosis.
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References
Anon. Antithrombin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 22/09/2016. Buckingham R (ed). Antithrombin III. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 22/09/2016. McEvoy GK, Snow EK, Miller J et al (eds). Antithrombin III (Human). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 22/09/2016. Thrombate III – Human (Grifols USA, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 22/09/2016.
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