May enhance blood-glucose lowering effect & increase susceptibility to hypoglycemia by oral antidiabetics, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates, sulfonamides. May reduce blood-glucose lowering effect by corticosteroids, danazol, diazoxide, diuretics, glucagon, INH, phenothiazine derivatives, somatropin, sympathomimetics (eg, epinephrine, salbutamol, terbutaline), thyroid hormones, estrogens, progestins, PIs, atypical antipsychotics (eg, olanzapine & clozapine). Blood glucose-lowering activity may either be potentiated or weakened by β-blockers, clonidine, lithium salts or alcohol. Hypoglycemia may sometimes followed by hyperglycemia w/ pentamidine. Reduced or absent signs of adrenergic counter-regulation w/ sympatholytics eg, β-blockers, clonidine, guanethidine, reserpine.
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