Advanced breast cancer in post-menopausal women w/ oestrogen receptor +ve &/or progesterone receptor +ve. Adjuvant treatment of post-menopausal women w/ hormone receptor +ve early invasive breast cancer. Adjuvant treatment of early breast cancer in hormone receptor +ve post-menopausal women who have received 2-3 yr of adjuvant tamoxifen.
Biochemically define menopause in any patient where there is doubt about menopausal status. Reduction in bone mineral density w/ a possible consequent increased risk of fractures. Formally assess bone mineral density by bone densitometry in women w/ or at risk of osteoporosis at the commencement of treatment & at regular intervals thereafter. Not to be taken by patients w/ rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption. May impair ability to drive or operate machinery. Not recommended in premenopausal women & childn.
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