Major depressive disorder. Patients w/ risk of bipolar disorders. NMS. DM. CV disease (a history of MI, ischemic heart disease, heart failure, conduction abnormality), cerebrovascular disease, predisposition of hypotension. Patients w/ a history of leucopenia/neutropenia, convulsion or lower seizure threshold. Patients w/ any risk of aspiration pneumonia. May impair the ability to drive vehicle or operate machinery. Elderly patients w/ psychosis-related dementia.