Not recommended in concomitant use w/ ritonavir. Systemic effects particularly at high doses for prolonged periods. Potential systemic steroid effects including ocular changes eg, central serous chorioretinopathy. Adrenal suppression w/ treatment higher than the recommended dose. Impaired adrenal function. Closely monitor patients w/ changes in vision or history of increased IOP, glaucoma &/or cataracts. May cause nasal mucosa irritation. Pregnancy & lactation. Maintain lowest dose for childn due to reduction in growth velocity. Childn <2 yr.