Bacampicillin

Oral
Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Meningitis, Otitis media, Paratyphoid fever, Perinatal streptococcal infections, Peritonitis, Pneumonia, Septicaemia, Typhoid fever, Urinary tract infections

Oral
Uncomplicated gonorrhoea

May be taken with or without food. May be taken w/ meals to reduce GI discomfort.

Infectious mononucleosis, lymphatic leukemia, HIV infection; hypersensitivity to penicillins.

Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitisation may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. Discontinue in case of skin rash.

Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Nausea; vomiting; pseudomembranous colitis.

Probenecid prolongs T_1/2 of bacampicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.

May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria.

Description:
Mechanism of Action: Bacampicillin has the antimicrobial action of ampicillin in vivo. It needs to be hydrolysed to ampicillin since it possesses no intrinsic activity.
Pharmacokinetics:
Absorption: Rapidly and absorbed in the GI tract.
Metabolism: Hydrolysed in intestinal walls and plasma to ampicillin.
Excretion: About 75% of a dose is excreted in the urine within 8 hr as ampicillin.

Penicillins