|
Indications and Dosage
Oral
Hypertension Adult: Initially, 5-10 mg once daily, may increase dose according to response. Usual maintenance: 10-20 mg once daily.
|
|
Administration
May be taken with or without food.
|
|
Contraindications
Cardiogenic shock; recent MI or acute unstable angina; severe aortic stenosis.
|
|
Special Precautions
Hypotension, poor cardiac reserve, heart failure. Sudden withdrawal may exacerbate angina. Discontinue in patients who experience ischaemic pain following admin. Pregnancy, lactation.
|
|
Adverse Reactions
Dizziness; flushing; headache; hypotension; peripheral oedema; tachycardia; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression; ischaemic chest pain; cerebral or myocardial ischaemia; transient blindness; rashes; fever; abnormal liver function; gingival hyperplasia; myalgia; tremor; impotence.
|
|
Drug Interactions
Other antihypertensives; aldesleukin; antipsychotics that cause hypotension; may modify insulin and glucose responses; quinidine; carbamazepine; phenytoin; rifampicin; cimetidine; erythromycin.
|
|
Lab Interference
Falsely elevated spectrophotometric values of urinary vanillylmandelic acid.
|
|
Action
Description:
Mechanism of Action: Barnidipine is a dihydropyridine calcium-channel blocker. It is a peripheral and coronary vasodilator, but has little or no effect on cardiac conduction and -ve inotropic activity is rarely seen at therapeutic doses. admin primarily results in vasodilatation, with reduced peripheral resistance, BP, and afterload, increased coronary blood flow, and a reflex increase in heart rate. This results in an increase in myocardial O2 supply and cardiac output. |
|
MIMS Class
|
Sign Out
