Active duodenal ulcer, active benign gastric ulcer, symptomatic erosive or ulcerative GERD. GERD maintenance. Symptomatic treatment of moderate to severe GERD, in combination w/ appropriate antibacterial therapeutic regimens for the eradication of H. pylori in patients w/ PUD.
Dosage/Direction for Use
Adults Active duodenal ulcer & active benign gastric ulcer Recommended dose: 20 mg once daily in the morning before eating. Some patients w/ active duodenal ulcer may respond to 10 mg in the morning before eating once daily. Erosive or ulcerative GERD Recommended dose: 20 mg once daily in the morning before eating for 4-8 wk. GERD maintenance 10 or 20 mg once daily in the morning before eating. Symptomatic GERD 10 mg once daily in the morning before eating in patients w/o esophagitis. Eradication of H. pylori 20 mg twice daily + clarithromycin 500 mg twice daily & amoxicillin 1 g twice daily for 7 days.
Administration
May be taken with or without food: Swallow whole, do not chew/crush.
Special Precautions
Possible gastric or esophageal malignancy should be excluded prior to commencing treatment. Observe patients on long-term treatment (>1 yr) during administration & the cumulative dose should be kept to a min in accordance w/ the disease condition.
Adverse Reactions
New-onset or exacerbation of subacute cutaneous & SLE, osteoporosis related bone fractures, fundic gland polyps, acute interstitial nephritis, Clostridium difficile-associated diarrhoea in hospitalised patients; diarrhoea, vomiting, nausea, abdominal pain, constipation, flatulence.
A02BC04 - rabeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
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