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Indications and Dosage
Oral
Angina pectoris Adult: 4 mg bid. Oral Hypertension Adult: 2-4 mg once daily increased to 8 mg once daily, if necessary.
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Administration
Should be taken with food.
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Contraindications
Pregnancy and lactation.
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Special Precautions
Elderly. In case of dizziness or lightheadedness, advise patients against handling of heavy machines or working at elevated spots. Reduce dosage gradually while withdrawing drug. Liver function tests.
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Adverse Reactions
Palpitation, facial flushing, hot flushes, chest pressure sensation, headache, dizziness, sleepiness, constipation, nausea, abdominal discomfort, oedema, malaise, tinnitus, redness and warm feeling in the fingers, shoulder stiffness, increased frequency of micturition. Hypersensitive reactions e.g. rash and itching. Elevation of SGOT, SGPT, alkaline phosphatase, total bilirubin, creatinine and uric acid.
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Drug Interactions
β-blockers or diuretics may enhance BP control. Serum concentrations of digoxin may be increased. Cimetidine may inhibit benidipine metabolism.
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Action
Description:
Mechanism of Action: The vasorelaxant effect of benidipine is due to its affinity towards dihydropyridine binding sites in calcium channels. Binding of benidipine with calcium channels inhibits calcium current. The onset of action is slow, which results in minimal tachycardia or palpitation. |
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MIMS Class
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