Benzoyl peroxide: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Acne vulgaris

Adult: As 2.5-10% preparations: Apply or use 1-2 times daily or as directed to the affected areas. May initiate treatment with lower strength preparations. Dosage recommendations and directions for use may vary among individual products (refer to specific product guideline).
Child: ≥12 years Same as adult dose. Recommendations for use in children may vary among individual products (refer to specific product guidelines for further information).

Contraindications

Hypersensitivity.

Special Precautions

Application to the neck and other sensitive areas. Concomitant use with other topical acne therapy. Children. Pregnancy and lactation.

Adverse Reactions

Significant: Increased sensitivity to sunlight, skin peeling, redness, swelling, or dryness; mild burning sensation.
Skin and subcutaneous tissue disorders: Allergic contact dermatitis.
Potentially Fatal: Rarely, allergic reactions, severe irritation.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Avoid contact with eyes, eyelids, mouth, lips, and other mucous membranes, or broken skin. Avoid deliberate or prolonged exposure to sunlight or UV radiation; use sunscreen and wear protective clothing. May bleach hair and coloured fabrics; avoid contact with hair, clothing, furniture or carpeting.

Overdosage

Symptom: Severe skin irritation. Management: Symptomatic treatment. Discontinue use and apply cold compress.

Drug Interactions

May reduce the efficacy of tretinoin, isotretinoin, and tazarotene. May result in temporary skin and facial hair discolouration (yellow/orange) when used concomitantly with sulfonamide- or sulfone-containing products.

Action

Description:
Mechanism of Action: Benzoyl peroxide is a highly lipophilic oxidising agent that has mild keratolytic effect and antimicrobial activity against Staphylococcus epidermidis and Propionibacterium acnes. Its antibacterial activity is due to the release of free-radical oxygen which oxidises bacterial protein in the sebaceous follicles reducing the number of anaerobic bacteria and irritating-type free fatty acids.
Pharmacokinetics:
Absorption: Approx 5% is absorbed through the skin.
Metabolism: Metabolised in the skin to benzoic acid.
Excretion: Via urine.

Chemical Structure

Storage

Store between 15-30°C. Storage recommendations may vary among individual products. Refer to specific product guideline.

MIMS Class

Acne Treatment Preparations

ATC Classification

D10AE01 - benzoyl peroxide ; Belongs to the class of topical peroxide preparations used in the treatment of acne.

References

111 Medco Benzoyl Peroxide Soap (111 Medco, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 22/03/2021.

Acnecide 5% w/w Gel (Galderma [UK] Limited). MHRA. https://products.mhra.gov.uk. Accessed 19/03/2021.

Anon. Benzoyl Peroxide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 03/02/2021.

Benzac AC (Galderma Hong Kong Ltd). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 22/03/2021.

Buckingham R (ed). Benzoyl Peroxide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/02/2021.

Enzoderm 5% Gel (Dermal Laboratories). MHRA. https://products.mhra.gov.uk. Accessed 19/03/2021.

Joint Formulary Committee. Benzoyl Peroxide. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/02/2021.

Neutrogena Acne Control Lotion (Johnson & Johnson Consumer Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/02/2021.

Neutrogena Clear Pore Cleanser Mask (Johnson & Johnson Consumer Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/02/2021.

Oxy Cover Cream (Rohto-Mentholatum [M] Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 22/03/2021.

Oxy Lotion (Rohto-Mentholatum [M] Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 22/03/2021.

PanOxyl 5 Cream (GlaxoSmithKline Consumer Healthcare UK Trading Limited). MHRA. https://products.mhra.gov.uk. Accessed 03/02/2021.

PanOxyl Aquagel 2.5% w/w Gel (GlaxoSmithKline Consumer Healthcare UK Trading Limited). MHRA. https://products.mhra.gov.uk. Accessed 03/02/2021.

Panoxyl Cream (Crown Laboratories). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/02/2021.

Panoxyl Soap (Physicians Total Care, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/02/2021.

PanOxyl Wash 10% w/w Lotion (GlaxoSmithKline Consumer Healthcare UK Trading Limited). MHRA. https://products.mhra.gov.uk. Accessed 03/02/2021.

Disclaimer: This information is independently developed by MIMS based on Benzoyl peroxide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com