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Indications and Dosage
Oral
Nutritional supplementation Adult: Usually incorporated in margarine, yogurt and foods: 1.5-3 g daily.
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Special Precautions
Safety and efficacy are not established in pregnancy and lactation. Caution when used in patients with asthma or breathing disorders, DM, primary biliary cirrhosis, ileostomy, neurodegenerative disorders (like Parkinsonism or Alzheimer's disease), diverticular disease, short bowel syndrome, celiac disease and sitosterolaemia. History of gallstones.
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Adverse Reactions
May cause constipation, diarrhoea, difficulty breathing and nausea.
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Drug Interactions
Activated charcoal may slightly reduce serum levels of beta sitosterol. Concurrent admin with ezetimibe may reduce serum levels of beta sitosterol in patients with sitosterolaemia. May have synergistic effects when used with HMG-coenzyme A reductase inhibitors.
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Food Interaction
May reduce absorption of fat-soluble vitamins e.g. carotenes and vitamin E.
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Action
Description:
Mechanism of Action: Beta-sitosterol is a plant sterol that is commonly found in fruits, vegetables, soybeans, breads, peanuts and peanut products. It is also found in bourbon and oils e.g. olive and flaxseed. It is reported to lower cholesterol and aid in symptomatic improvement in mild to moderate benign prostatic hypertrophy. |
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Storage
Store below 25°C.
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MIMS Class
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