Betamethasone + Fusidic acid: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Corticosteroid-responsive dermatoses with secondary infection

Adult: Available preparations
Each cream contains betamethasone valerate 0.1 % and fusidic acid 2%
Each cream contains betamethasone dipropionate 0.064% and fusidic acid 2%
Each oint contains betamethasone dipropionate 0.064% and sodium fusidate 2%

Apply onto affected area(s) bid. Max duration: 2 weeks.

Contraindications

Skin lesions of viral, fungal or bacterial origin (e.g. herpes or varicella), skin manifestations in relation to TB or syphilis, perioral dermatitis and rosacea, ulcerative condition.

Special Precautions

May increase risk of developing antibiotic resistance. Stasis dermatitis and other skin disease w/ impaired circulation. Not to be used for >7 days if there is no clinical improvement. Avoid prolonged continuous treatment esp in infants and childn. Pregnancy and lactation.

Adverse Reactions

Hypersensitivity, contact dermatitis, eczema (aggravated condition), skin burning sensation, pruritus, dry skin, application site pain or irritation. Rarely, erythema, urticaria (including rash erythematous and generalised rash), application site swelling or vesicles.

Patient Counseling Information

Avoid contact w/ eyes as it may cause glaucoma.

Overdosage

Symptoms: Cushing's syndrome and adrenocortical insufficiency. Management: Symptomatic treatment.

Action

Description:
Mechanism of Action: Betamethasone is a topical fluorinated corticosteroid that has an anti-inflammatory and antipruritic effect. Fusidic acid is a potent topical antibacterial agent which is effective against Staphylococcus aureus, Streptococci, Corynebacteria, Neiserria and certain Clostridia and Bacteroides.
Pharmacokinetics:
Absorption: Betamethasone: Absorption through the skin is increased under occlusive dressing or when there is broken skin at the site of application.
Distribution: Betamethasone: Bound to plasma proteins to varying extent. Fusidic acid: Widely distributed into tissues and body fluids (including bone, pus, synovial fluid); penetrate cerebral abscesses but does not enter cerebrospinal fluid in appreciable amounts. Enters foetal circulation and breast milk. Plasma protein binding: Approx ≥95% as fusidic acid or Na fusidate.
Metabolism: Betamethasone: Mainly metabolised in the liver and limited extent in the kidneys.
Excretion: Betamethasone: Via urine as inactive metabolites. Fusidic acid/Na fusidate: Mainly in the bile via faeces (approx 2%) as unchanged drug; urine (small amounts).

Chemical Structure

Storage

Store at or below 30°C. Protect from light.

MIMS Class

Topical Anti-Infectives with Corticosteroids

References

Fobancort (Hoe Pharma/Taisho PharmaceuticaL). MIMS Singapore. http://www.mims.com/singapore. Accessed 07/08/2015.

Leo Pharma Ltd. Fucicort Cream data sheet January 2016. Medsafe. http://www.medsafe.govt.nz/. Accessed 07/08/2015.

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