Betamethasone + Salicylic acid

Topical/Cutaneous
Corticosteroid-responsive dermatoses, Hyperkeratotic and scaling skin conditions, Inflammatory skin conditions

Viral skin infections (e.g. vaccinia, varicella and herpes simplex), TB, acne, rosacea, napkin eruptions, fungal or bacterial skin infections w/o suitable concomitant anti-infective therapy, perioral dermatitis, ulcerative conditions, perianal and genital pruritus.

Absorption of corticosteroid through the skin is increased when used w/ occlusive dressings. Avoid long term continuous therapy. Childn. Pregnancy and lactation.

Irritation, burning, itching, dryness, folliculitis, maceration of skin, skin atrophy, hypertrichosis, acneiform eruptions, secondary infection, hypopigmentation, perioral dermatitis, allergic contact dermatitis, striae and miliaria.

Avoid contact w/ the eyes and mucous membranes.

Symptoms: Pituitary-adrenal suppression resulting in secondary adrenal insufficiency and produce manifestations of hypercorticism, including Cushing's disease. Salicyclism symptoms. Management: Symptomatic and supportive treatment. Treat electrolyte imbalance. Slow withdrawal in case of chronic toxicity. Admin oral Na bicarbonate to alkalinise the urine and force diuresis.

Description:
Mechanism of Action: Betamethasone is a synthetic fluorinated corticosteroid. It is active topically and produces a rapid and sustained response in inflammatory dermatoses. Salicylic acid has keratolytic action. It softens keratin, loosens cornified epithelium and desquamates the epidermis. It aids in the penetration of betamethasone.
Pharmacokinetics:
Absorption: Betamethasone: Percutaneous absorption depends on several factors e.g. use of occlusive dressings and integrity of the epidermal barrier. Salicylic acid: Exerts only local action after topical application.
Distribution: Betamethasone: Rapidly distributed to all body tissues. Crosses the placenta; enters breast milk (small amounts). Plasma protein binding: Extensive (mainly to globulin).
Metabolism: Betamethasone: Metabolised mainly in the liver.
Excretion: Betamethasone: Via urine; may also be excreted via the bile.

Source: National Center for Biotechnology Information. PubChem Database. Betamethasone, CID=9782, https://pubchem.ncbi.nlm.nih.gov/compound/Betamethasone (accessed on Jan. 21, 2020)

Source: National Center for Biotechnology Information. PubChem Database. Salicylic acid, CID=338, https://pubchem.ncbi.nlm.nih.gov/compound/Salicylic-acid (accessed on Jan. 21, 2020)

Store at or below 25°C.

Topical Anti-Infectives with Corticosteroids

Betosalic Ointment (T.O. Chemicals). MIMS Thailand. http://www.mims.com/thailand. Accessed 07/08/2015.

Buckingham R (ed). Pharmacokinetics of Corticosteroids. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/08/2015.

McEvoy GK, Snow EK, Miller J et al (eds). Betamethasone, Betamethasone Benzoate, Betamethasone Dipropionate, Betamethasone Valerate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 07/08/2015.