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Indications and Dosage
Intravenous
Ventricular tachycardia Adult: Given as internittent IV bolus inj, 40 mg every 5 minutes. Max total dose: 5 mg/kg.
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Contraindications
Phaeochromocytoma, heart failure not caused by hypertension.
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Special Precautions
Renal impairment, cerebrovascular disorders, ischaemic heart disease, history of peptic ulceration or asthma. Hypotensive effect may be increased by exercise and heat. Increased risk of CV collapse or cardiac arrest in patients undergoing surgery.
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Adverse Reactions
Severe postural and exertional hypotension, diarrhoea, dizziness, syncope, muscle weakness, lassitude, angina, renal insufficiency, transient cerebral ischaemia, bradycardia, failure of ejaculation, fatigue, headache, salt and water retention, oedema, breathlessness, overt heart failure, nausea, vomiting, dry mouth, nasal congestion, parotid tenderness, blurring of vision, depression, myalgia, muscle tremor, paraesthesias, hair loss, dermatitis, disturbed micturition, priapism, aggravation or precipitation of asthma, exacerbation of peptic ulcer, haematological effects.
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Drug Interactions
Adrenaline, amfetamine, other sympathomimetics, TCAs, MAOIs, phenothiazine derivatives and related antipsychotics, oral contraceptives, digoxin or other digitalis derivatives, thiazide diuretics, other antihypertensives, levodopa, alcohol.
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Action
Description:
Mechanism of Action: Betanidine acts by selectively inhibiting transmission in postganglionic adrenergic nerves. It acts mainly by preventing the release of noradrenaline at nerve endings; it causes depletion of noradrenaline stores in the peripheral sympathetic nerve terminals. It does not prevent the release of catecholamines by the adrenal medulla. |
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MIMS Class
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