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Indications and Dosage
Oral
H. pylori infection Adult: 300 mg once daily or 75 mg 4 times daily. Usually used in combination with other drugs as part of the triple therapy.
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Renal Impairment
Moderate-severe impairment: Avoid use.
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Contraindications
Impaired renal function; pregnancy (3rd trimester).
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Special Precautions
Monitor renal function regularly.
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Adverse Reactions
Nausea, vomiting, methemoglobinaemia, encephalopathy, bone and joint toxicity, darkening or blackening of faeces.
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Overdosage
Overdosage may lead to serious adverse effects such as renal failure, encephalopathy and neurotoxicity. May consider gastric lavage, purgation and hydration. Chelating agents may be useful.
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Drug Interactions
Increased absorption with antisecretory drugs. Reduces absorption of tetracyclines.
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Action
Description:
Mechanism of Action: Bismuth subnitrate has been used for its supposed antacid and mildly astringent action in various GI disorders. It has also been used topically in the treatment of skin disorders, wounds, burns, haemorrhoids and other anorectal disorders. Pharmacokinetics: Absorption: Poor absorption in the GI tract. Increased gastric pH may increase bismuth absorption. Distribution: Distributed throughout the body tissues, including bone. Excretion: Unabsorbed bismuth is excreted in the faeces. Plasma half-life: about 5 days. |
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MIMS Class
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