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Indications and Dosage
Oral
Angina pectoris, Hypertension Adult: 0.5-2 mg daily.
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Contraindications
2nd and 3rd ° AV block; sinus bradycardia; uncontrolled heart failure; bronchospasm or asthma, metabolic acidosis, severe peripheral arterial disease, phaeochromocytoma.
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Special Precautions
1st ° AV block. May mask symptoms of hyperthyroidism and hypoglycaemia. May unmask myasthenia gravis. May aggravate psoriasis. Gradual withdrawal over 1-2 wk is advisable otherwise, it may result in angina, MI, ventricular arrhythmias and death. Pregnancy and lactation.
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Adverse Reactions
Bradycardia; hypotension; heart failure, heart block; bronchospasm; fatigue; coldness of extremities; pneumonitis; pulmonary and retroperitoneal fibrosis; pleurisy; CNS effects; myopathies; GI disturbances; skin rash; pruritus; reversible alopoecia; lupus-like syndrome; male impotence; sclerosing peritonitis; paraesthesias; peripheral neuropathy; muscle cramps; haematological reactions.
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Drug Interactions
Drugs that cause hypotension; NSAIDs; other cardiac depressants; sotalol; digoxin; insulin and oral hypoglycaemics; sympathomimetics; ACE inhibitors; calcium-channel blockers, verapamil. Anaesthetics that cause myocardial depression (e.g. ether, cyclopropane, trichloroethylene).
Potentially Fatal: Increased risk of withdrawal HTN with clonidine. (Withdraw several days before slowly withdrawing clonidine). |
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Lab Interference
Changes in blood concentrations of triglycerides, glucose and cholesterol.
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Action
Description:
Mechanism of Action: Bopindolol is a non-cardioselective β-blocker with some intrinsic sympathomimetic activity. |
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MIMS Class
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