Bucillamine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Rheumatoid arthritis

Adult: Initially 100 mg/day.

Adverse Reactions

Skin and kidney disorders; pemiphigus lesions.

Action

Description:
Mechanism of Action: Bucillamine is structurally related to penicillamine & is reported to be an immunomodulator. It has been used in RA. It inhibits hypoxic induction of Vascular Endothelial Growth Factor (VEGF) through inhibition of Hypoxia Inducible Factor HIF-1 induction & binding activity in Bovine Retinal Microcapillary Endothelial Cells (BREC). It also inhibits the spontaneous expression of VEGF mRNA by its effect on Sp1 & Hypoxia Responsive Element (HRE) binding.

MIMS Class

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

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