Concomitant use w/ β-blockers (eg, propanolol) may cause bronchospasm. Do not use in combination w/ other xanthines. Increased plasma conc w/ cimetidine, ciprofloxacin, clarithromycin, norfloxacin, erythromycin, troleandomycin & OCs. Decreased plasma conc w/ rifampicin, verapamil & diltiazem.