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Indications and Dosage
Intramuscular
Cerebrovascular and peripheral vascular disease Adult: Up to 100 mg daily. Intravenous Cerebrovascular and peripheral vascular disease Adult: Up to 200 mg daily by slow IV Inj or up to 400 mg daily by IV infusion. Oral Cerebrovascular and peripheral vascular disease Adult: 300-600 mg daily.
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Special Precautions
May affect ability to drive or operate machinery. Renal or hepatic impairment.
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Adverse Reactions
GI disturbances, headache, vertigo, syncope, rash, pruritus, paraesthesia, cephalea, lightheadednesss, dizziness, itching, flushing.
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Overdosage
Overdosage may lead to tachycardia, severe hypotension and convulsions.
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Drug Interactions
Synergism with antihypertensives.
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Action
Description:
Mechanism of Action: Buflomedil enhances RBC deformibility, muscle cell metabolism as well as platelet inhibition, thus bringing about vasodilating effects. Pharmacokinetics: Absorption: Absorbed from the GI tract; plasma concentrations peaked at 1.5-4 hr after oral admin. Distribution: Widely distributed. Plasma proetin binding: Dose-dependent and ranges from 60-80%. Metabolism: Metabolised hepatically. Excretion: Elimination half-life: 2-3 hr. Mainly excreted in the urine as unchanged drug and metabolites. |
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