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Indications and Dosage
Oral
Type 2 diabetes mellitus Adult: Up to 300 mg daily.
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Administration
Should be taken with food.
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Contraindications
Diabetic coma; ketoacidosis; severe infection; trauma; other severe infections where buformin is unlikely to control the hyperglycaemia; renal or hepatic impairment; heart failure; recent MI; dehydration; alcoholism; conditions likely to predispose to lactic acidosis.
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Special Precautions
Stop treatment temporarily 48 hrs before examinations using contrast media. Monitor renal function throughout therapy. Annual monitoring of vit B12 concentrations during long-term treatment.
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Adverse Reactions
Anorexia; nausea; diarrhoea; hypoglycaemia; metallic taste; wt loss.
Potentially Fatal: Lactic acidosis. |
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Drug Interactions
Drugs that may impair renal function. Increased risk of lactic acidosis and hypoglycaemia with alcohol. Other hypoglycaemics; hyperglycaemics.
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Action
Description:
Mechanism of Action: Buformin delays absorption of glucose from the GI tract, increases insulin sensitivity and glucose uptake into cells and inhibits hepatic gluconeogenesis. |
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MIMS Class
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