Butenafine: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Skin fungal infections

Adult: As 1% cream: Tinea corporis and tinea cruris: Apply to affected and surrounding area once daily for 2 weeks. Tinea pedis: Apply to affected skin between and around the toes bid for 1 week or once daily for 4 weeks. Tinea versicolor: Apply to affected and surrounding area once daily for 1-2 weeks.
Child: ≥12 years Same as adult dose.

Contraindications

Hypersensitivity to butenafine.

Special Precautions

Patient with allylamine antifungal (e.g. naftifine, terbinafine) hypersensitivity. Children. Pregnancy and lactation. Not intended to be used on nails, scalp, near mouth or eyes, or for vaginal yeast infections.

Adverse Reactions

Significant: Irritation, sensitivity.
Skin and subcutaneous tissue disorders: Burning or stinging sensation, itching, erythema. Rarely, contact dermatitis.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Avoid contact with eyes or other mucous membranes. Avoid occlusive dressings.

Monitoring Parameters

Perform culture and potassium hydroxide (KOH) examination. Assess for clinical signs of tinea pedis.

Action

Description:
Mechanism of Action: Butenafine, a synthetic benzylamine antifungal, exhibits its fungicidal activity by inhibiting squalene epoxidation thereby blocking ergosterol synthesis and subsequent weakening of fungal cell membranes.
Pharmacokinetics:
Absorption: Minimal systemic absorption. Time to peak serum concentration: 6-15 hours.
Metabolism: Metabolised in the liver via hydroxylation.
Excretion: Elimination half-life: Biphasic: 35 hours (α); >150 hours (β).

Chemical Structure

Storage

Store between 20-25°C. Storage recommendations may vary among individual products. Refer to specific product guidelines.

MIMS Class

Topical Antifungals & Antiparasites

ATC Classification

D01AE23 - butenafine ; Belongs to the class of other antifungals for topical use.

References

Anon. Butenafine Hydrochloride. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 26/04/2023.

Anon. Butenafine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 26/04/2023.

Buckingham R (ed). Butenafine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 26/04/2023.

Lotrimin Ultra Athletes Foot Cream (Bayer Healthcare LLC.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 26/04/2023.

Lotrimin Ultra Jock Itch Cream (Bayer Healthcare LLC.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 26/04/2023.

Mentax Cream (Mylan Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 26/04/2023.

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