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Indications and Dosage
Oral
Oedema Adult: 5-10 mg daily, may be used with other diuretics. Oral Hypertension Adult: 2.5-7.5 mg daily, may be used with other antihypertensives.
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Contraindications
Severe hepatic impairment and renal decompensation. Addison's disease.
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Special Precautions
Existing fluid and electrolyte disturbances, patients who are at risk from changes in fluid and electrolytes. DM, hypercholesterolaemia, SLE, may precipitate gout.
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Adverse Reactions
Orthostatic hypotension, Photosensitivity, hypokalaemia, anorexia, epigastric distress.
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Drug Interactions
Concurrent use with colestipol and cholestyramine may reduce absorption of butizide. Ciclosporin can potentiate the risk of renal toxicity and gout. Efficacy may be reduced by NSAIDs. May enhance toxicity of cardiac glycosides and risk of arrhythmias associated with drugs that prolong QT interval. May increase neuromuscular blocking action of competitive neuromuscular blockers e.g. atracurium. Hypokalaemic effect may be potentiated by corticosteroids, corticotropin, β2 agonists, carbenoxolone, amphotericin B or reboxetine. Concurrent use with lithium may lead to lithium toxicity.
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Action
Description:
Mechanism of Action: Butizide is a thiazide diuretic that works by inhibiting sodium reabsorption in the distal tubules, resulting in increased excretion of sodium and water as well as potassium and hydrogen ions. It is used in the treatment of oedema and hypertension. |
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MIMS Class
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