Butoconazole: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Vaginal
Vulvovaginal candidiasis

Adult: As 2% cream: Apply approx 5 g intravaginally for 3 consecutive nights or as a single dose.

Contraindications

Hypersensitivity.

Special Precautions

Women w/ recurrent infections or those having 1st-time vag yeast infection. Childn <12 yr. Pregnancy and lactation.

Adverse Reactions

Vulvovaginal burning, itching, soreness and swelling, pelvic or abdominal pain or cramping. Severe reversible thrombocytopenia. Rarely, headache, urinary frequency and burning, vulvovaginal discharge, irritation, stinging and odor.

Pregnancy Category (US FDA)

Vag: C

Patient Counseling Information

May weaken latex or rubber products (e.g. condoms, vag contraceptive diaphragms), do not use w/in 72 hr of treatment. Avoid contact w/ eyes.

Action

Description:
Mechanism of Action: Butoconazole, a synthetic azole antifungal, is usually fungistatic in action but may have growth phase-dependent fungicidal activity at high concentrations or against very susceptible organisms. It exerts its fungistatic activity by interfering w/ ergosterol synthesis and altering cellular membranes. It also has some antibacterial activity against gm+ve organisms.
Pharmacokinetics:
Absorption: Approx 5% is absorbed after vag use.
Excretion: Plasma half-life: 21-24 hr.

Chemical Structure

Storage

Store between 15-30°C.

MIMS Class

Preparations for Vaginal Conditions

References

Anon. Butoconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/07/2014.

Buckingham R (ed). Butoconazole Nitrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/07/2014.

Gynazole Cream (Ther-Rx Corporation). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 21/07/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Butoconazole Nitrate (Vaginal). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 21/07/2014.

Wickersham RM. Butoconazole Nitrate. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 21/07/2014.

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