AdultPneumonia, UTI, gynecological infections eg, endometritis, skin & skin structure infections 500 mg IV 8 hrly. Nosocomial pneumonia, peritonitis, septicemia, presumed infections in neutropenic patients 1 g IV 8 hrly. Meningitis 2 g IV 8 hrly. Renal impairment: CrCl 26-50 mL/min 1 unit dose 12 hrly, 10-25 mL/min ½-1 unit dose 12 hrly, <10 mL/min ½-1 unit dose 24 hrly. Childn >3 mth up to 12 yr 10-20 mg/kg 8 hrly depending on type & severity of infection, susceptibility of the pathogen & condition of the patient. >50 kg Same as adult dose. Meningitis 40 mg/kg 8 hrly.
Contraindications
Hypersensitivity.
Special Precautions
Hypersensitivity to β-lactams. Do not use for infections due to MRSA. Monitor serum hepatic levels in patients w/ hepatic disease. Consider diagnosis of pseudomembranous colitis in patients who develop diarrhea. May impair ability to drive & operate machinery. Pregnancy & lactation. Infant <3 mth.
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