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Indications and Dosage
Oral
Gastro-oesophageal reflux disease Adult: 20 mg tid. Topical/Cutaneous Mouth ulceration Adult: Apply 2% gel 4 times daily.
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Contraindications
Hypokalaemia; cardiac failure and in those receiving cardiac glycosides. Pregnancy, elderly, child <3 yrs.
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Special Precautions
Cardiac disease, hypertension, impaired hepatic or renal function.
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Adverse Reactions
Sodium and water retention, hypokalaemia.
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Drug Interactions
Antagonism with amiloride and spironolactone. Exacerbates hypokalaemia associated with diuretics.
Potentially Fatal: Risk of toxicity with digitalis glycosides. |
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Action
Description:
Mechanism of Action: Carbenoxolone is a synthetic derivative of glycyrrhizinic acid (a constituent of liquorice). It acts by protecting the mucosal barrier from acid-pepsin attack and increasing mucosal mucin production. Pharmacokinetics: Absorption: Absobed in the GI tract, mainly from the stomach. Distribution: Highly bound to plasma proteins. Excretion: Mainly excreted in the faeces via the bile. |
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