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Indications and Dosage
Parenteral
Susceptible infections Adult: 0.5-1 g every 4-6 hr IM or IV; up to 12 g daily in severe infections.
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Renal Impairment
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Contraindications
Hypersensitivity to cephalosporins.
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Special Precautions
Hypersensitivity to penicillins; renal impairment; porphyria. Monitor renal and haematologic status.
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Adverse Reactions
Nausea; vomiting; diarrhoea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; pseudomembranous colitis; hepatic dysfunction; haematologic disorders; pain at Inj site (IM); thrombophloebitis (IV infusion); superinfection with prolonged use.
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Drug Interactions
Nephrotoxic drugs such as aminoglycosides may increase risk of kidney damage. Enhanced nephrotoxicity with a loop diuretic. Renal excretion inhibited by probenecid. Bacteriostatic antibacterials.
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Lab Interference
Positive direct antiglobulin Coombs' test; falsely high values with Jaffe method of measuring creatinine concentrations; +ve reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
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Action
Description:
Mechanism of Action: Cefapirin inhibits final cross-linking stage of peptidoglycan production thus inhibiting bacterial cell wall synthesis. It is most active against gm+ve cocci and has moderate activity against some gm-ve bacilli. |
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MIMS Class
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