|
Indications and Dosage
Oral
Susceptible infections Adult: 500 mg bid.
|
|
Contraindications
Hypersensitivity to cephalosporins.
|
|
Special Precautions
Hypersensitivity to penicillins; renal impairment; porphyria. Monitor renal and hematologic status. Pregnancy, lactation.
|
|
Adverse Reactions
Nausea; vomiting; diarrhoea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; pseudomembranous colitis; hepatic dysfunction; haematologic disorders; pain at Inj site (IM); thrombophloebitis (IV infusion); superinfection with prolonged use.
|
|
Drug Interactions
Renal excretion delayed by probenecid. Decreases contraceptive effect of estrogen-containing oral contraceptives.
|
|
Lab Interference
Positive direct antiglobulin Coombs' test; falsely high values with Jaffe method of measuring creatinine concentrations; +ve reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
|
|
Action
Description:
Mechanism of Action: Cefatrizine inhibits final cross-linking stage of peptidoglycan production thus inhibiting bacterial cell wall synthesis. It has excellent activity against gram-positive cocci except enterococci at minimal inhibitory concentrations <1 mcg/ml. |
|
MIMS Class
|
Sign Out
