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Indications and Dosage
Parenteral
Susceptible infections Adult: 1-4 g daily IM/IV by Inj or infusion in 2-4 divided doses, up to 9 g daily for severe infections.
Child: 40-80 mg/kg/day in 2-4 divided doses, higher doses may be used in severe infections. Neonates: 40-60 mg/kg/day in 2-3 divided doses. |
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Contraindications
Hypersensitivity to cephalosporins.
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Special Precautions
Hypersensitivity to penicillins; renal impairment; porphyria. Monitor renal and hematologic status. Pregnancy and lactation.
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Adverse Reactions
Nausea; vomiting; diarrhoea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; hepatic dysfunction; haematologic disorders; pain at Inj site (IM); thrombophloebitis (IV infusion); superinfection with prolonged use.
Potentially Fatal: Pseudomembranous colitis. |
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Drug Interactions
Renal clearance reduced by probenecid. Disulfiram-like reactions with alcohol.
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Lab Interference
Positive direct antiglobulin Coombs' test; falsely high values with Jaffe method of measuring creatinine concentrations; +ve reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
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Action
Description:
Mechanism of Action: Cefmenoxime inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is highly stable to hydrolysis by most β-lactamases. |
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MIMS Class
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