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Indications and Dosage
Parenteral
Anaerobic bacterial infections, Gonorrhoea, Mixed bacterial infections, Prophylaxis of anaerobic bacterial infections, Prophylaxis of mixed bacterial infections Adult: 0.5-1 g every 12 hr via IM inj or slow IV inj over 3-5 minutes. Severe infections: 3-4 g daily, given in divided doses every 6-8 hr. Dose can also be given via IV infusion over 10-60 minutes.
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Renal Impairment
Interval between doses: 12, 16, or 24 hr in patients with mild, moderate or severe renal impairment, respectively. Patients with virtually no renal function: dose may be given every 48 hr after hemodialysis.
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Contraindications
Hypersensitivity to cephalosporins.
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Special Precautions
History of allergy; porphyria; renal impairment. Monitor renal and haematological states during prolonged and high-dose thearapy. Lactation.
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Adverse Reactions
Hypersensitivity reactions; nephrotoxicity; neutropenia; thrombocytopenia; agranulocytosis; bleeding complications related to hypoprothrombinaemia or platelet dysfunction; GI effects; CNS toxicity; superinfection; pain at Inj site (IM); thrombophloebitis (IV infusion); hepatitis; cholestatic jaundice.
Potentially Fatal: Pseudomembranous colitis. |
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Drug Interactions
Disulfiram-like reaction with alcohol; may enhance hypoprothrombinemic response to anticoagulants; renal clearance reduced by probenecid.
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Lab Interference
Transient increases in liver enzyme values; false-positive reactions for glucose using copper-reduction reactions; positive direct Coombs' test. May produce falsely high values in Jaffe method of measuring creatinine concentration.
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Action
Description:
Mechanism of Action: Cefmetazole has similar spectrum of activity to that of cefoxitin, and includes Bacteroides fragilis. Pharmacokinetics: Distribution: 65-85% bound to plasma proteins. Excretion: Plasma half-life: 1.1-1.5 hr. Prolonged in renally impaired patients. Excreted unchanged in the urine. |
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MIMS Class
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