Cefotaxime + Sulbactam

Oral
Genitourinary infections, Lower respiratory tract infections

Dose adjustment may be needed.

Hypersensitivity to cefotaxime, sulbactam or the combination.

Previous hypersensitivity to penicillins or other drugs; patients with renal insufficiency; history of GI disease, esp colitis. Pregnancy and lactation.

Local reactions including pain at the Inj site and phloebitis. Others: Skin rash, diarrhoea, nausea, vomiting and colitis.

Concomitant admin of cephalosporins and aminoglycoside antibiotics.

Description:
Mechanism of Action: Cefotaxime is a bactericidal drug, which inhibits the bacterial wall synthesis of the actively dividing cells by binding to one or more penicillin-binding proteins. Sulbactam is a semisynthetic β-lactam sulphone, which inhibits β-lactamases of the Richmond types II, III, IV and V (plasmid or chromosomally mediated). This inhibition is reported to be both reversible and irreversible. It acts as a suicide inhibitor by forming a reversible inactive enzyme-sulbactam complex. This reversible acyl-intermediate may then revert to a more stable complex, which irreversibly inhibits the β-lactamase. Sulbactam is able to protect the activity of various β-lactam antibiotics by rendering β-lactamases inactive.

Cephalosporins