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Indications and Dosage
Oral
Prophylaxis of surgical infections, Susceptible infections Adult: 200-400 mg bid. Parenteral Prophylaxis of surgical infections, Susceptible infections Adult: As hydrochloride: Up to 6 g daily IV/IM in divided doses according to severity of infection. As hexetil hydrochloride: 200-400 mg bid.
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Renal Impairment
Parenteral:
Dose reduction may be needed. |
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Administration
Should be taken with food. Take just before meals.
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Contraindications
Hypersensitivity to cephalosporins.
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Special Precautions
Hypersensitivity to penicillins; renal impairment; porphyria. Monitor renal and haematologic status. May cause bleeding (reversible with vitamin K admin).
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Adverse Reactions
Nausea; vomiting; diarrhoea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; hepatic dysfunction; haematologic disorders; pain at Inj site (IM); thrombophloebitis (IV infusion); superinfection with prolonged use.
Potentially Fatal: Pseudomembranous colitis. |
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Drug Interactions
Disulfiram-like interaction with alcohol. May enhance hypoprothrombinaemic response to anticoagulants. Renal clearance reduced by probenecid.
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Lab Interference
Positive direct antiglobulin Coombs' test; falsely high values with Jaffe method of measuring creatinine concentrations; +ve reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
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Action
Description:
Mechanism of Action: Cefotiam inhibits final cross-linking stage of peptidoglycan production thus inhibiting bacterial cell wall synthesis. It has similar or less activity against gm+ve staphylococci and streptococci, but is resistant to some β-lactamases produced by gm-ve bacteria. It is more active against many of the Enterobacteriaceae including Enterobacter, E. coli, Klebsiella, Salmonella and indole-positive Proteus sp. |
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MIMS Class
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