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Indications and Dosage
Intramuscular
Susceptible infections Adult: 2-4 g daily in 2-3 divided doses.
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Contraindications
Hypersensitivity to cephalosporins.
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Special Precautions
Hypersensitivity to penicillins; renal impairment; porphyria. Monitor renal and haematological status.
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Adverse Reactions
Nausea; vomiting; diarrhea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; hepatic dysfunction; hematologic disorders; pain at injection site (IM); thrombophlebitis (IV infusion); superinfection with prolonged use.
Potentially Fatal: Pseudomembranous colitis. |
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Drug Interactions
Renal excretion inhibited by probenecid. Bacteriostatic antibacterials.
Potentially Fatal: Nephrotoxic drug eg. aminoglycoside may increase risk of kidney damage. Enhanced nephrotoxicity with a loop diuretic. |
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Lab Interference
Positive direct antiglobulin Coombs' test; falsely high values w/ Jaffe method of measuring creatinine conc; +ve reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
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Action
Description:
Mechanism of Action: Ceftezole has properties similar to cefalotin. It is active against S. aureus, S. pneumoniae, E. coli, Proteus mirabilis. |
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MIMS Class
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