Celiprolol

Oral
Hypertension

CrCl (mL/min)	Dosage
<15	Avoid.
15-40	100-200 mg/day.

Should be taken on an empty stomach. Take at least 30 min before or 2 hr after meals.

Heart block (2nd or 3rd degree), sick-sinus syndrome, cardiogenic shock, uncontrolled heart failure, severe bradycardia, severe renal impairment (CrCl <15 mL/min), acute episodes of asthma, untreated phaeochromocytoma, metabolic acidosis, hypotension, or severe peripheral arterial circulatory disturbances.

Patients w/ 1st degree heart block, well-controlled CHF, DM, untreated phaeochromocytoma, history of psoriasis. Avoid abrupt withdrawal as it may increase the risk of angina. Patients undergoing surgery involving general anaesth. May mask symptoms of hypoglycaemia and thyrotoxicosishyperthyroidism. Hepatic and mild to moderate renal impairment. Pregnancy and lactation.

Headache, fatigue, dizziness, hot flushes, asthenia, somnolence and insomnia; tremor and palpitations; bronchospasm, skin rashes and/or visual disturbances. Rarely, depression, hypersensitivity, pneumonitis.

Monitor BP and ECG.

May exacerbate rebound HTN upon withdrawal of clonidine. May increase AV conduction time w/ digitalis glycosides. Reduced bioavailability w/ concomitant hydrochlorothiazide, chlorthalidone or theophylline. Concomitant dihydropyridine Ca channel blockers (e.g. nifedipine) may increase the risk of hypotension and heart failure.

May cause false-positive result in drug screening test.

Description:
Mechanism of Action: Celiprolol is a cardioselective β-blocker. It exhibits intrinsic sympathomimetic and direct vasodilator activity.
Pharmacokinetics:
Absorption: Incompletely absorbed from the GI tract. Food may impair its bioavailability.
Distribution: Crosses the placenta. Plasma protein binding: Approx 25%.
Metabolism: Minimal metabolism.
Excretion: Via urine and faeces (as unchanged drug). Elimination half-life: Approx 5-6 hr.

Store below 25°C.

Beta-Blockers

Anon. Celiprolol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/12/2013.

Buckingham R (ed). Celiprolol HCl. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/12/2013.

Joint Formulary Committee. Celiprolol HCl. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/12/2013.