Chlorcyclizine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Allergic conditions

Adult: 25 mg 6-8 hrly. Max: 75 mg 24 hrly.
Child: 6-11 yr 12.5 mg 6-8 hrly. Max: 37.5 mg 24 hrly; ≥12 yr Same as adult dose.

Oral
Motion sickness

Child: ≥6 yr As chewable tab: 25 mg 6-8 hrly taken up to 1 hr before travel or at onset of symptoms.

Contraindications

Emphysema, chronic bronchitis, glaucoma, enlarged prostate gland.

Special Precautions

Childn. Pregnancy and lactation.

Adverse Reactions

Significant: Drowsiness, excitability.

Patient Counseling Information

This drug may cause drowsiness, if affected, do not drive or operate machinery.

Drug Interactions

May enhance the action of epinephrine.

Action

Description:
Mechanism of Action: Chlorcyclizine, a piperazine derivative, is a sedating antihistamine given for the symptomatic relief of hypersensitivity reactions. Additionally, it has some local anaesthetic, anticholinergic, antiserotonergic properties, and can be used as an antiemetic.
Pharmacokinetics:
Absorption: Readily absorbed. Time to peak plasma concentration: 5 hr.
Distribution: Widely distributed throughout the body. Plasma protein binding: 85-90%.
Metabolism: Metabolised via N-demethylation to norchlorcyclizine and via N-oxidation to chlorcyclizine N-oxide.
Excretion: Via urine (as norchlorcyclizine and approx 0.5% as chlorcyclizine N-oxide).

Chemical Structure

Storage

Store between 20-25°C.

MIMS Class

Antiemetics / Antihistamines & Antiallergics

ATC Classification

R06AE04 - chlorcyclizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.

References

Ahist Tablet (Magna Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 21/02/2017.

Bonine Kids Tablet, Chewable (Insight Pharmaceuticals). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 21/02/2017.

Buckingham R (ed). Chlorcyclizine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/02/2017.

Chlorcyclizine. National Center for Biotechnology Information. PubChem Database. https://pubchem.ncbi.nlm.nih.gov/. Accessed 21/02/2017.

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