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Indications and Dosage
Oral
Prostate cancer, Prostatic hyperplasia Adult: 25 or 50 mg bid. Oral Menstrual disorders Adult: As acetate: 2-10 mg/day alone or in combination with an oestrogen, either cyclically or continuously. Oral Part of combined oral contraceptive Adult: 1-2 mg/day.
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Contraindications
History of liver tumors, severe liver impairment, genital tract or breast carcinoma (unless progestogens are being used as part of the management of these conditions), arterial disease, undiagnosed vaginal bleeding and porphyria. Pregnancy, pregnancy testing, missed or incomplete abortion.
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Special Precautions
CV or renal impairment, DM, asthma, epilepsy, migraine, other conditions which may be aggravated by fluid retention, history of depression. Lactation.
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Adverse Reactions
GI and menstrual disturbances, wt gain, fluid retention, acne, melasma, allergic skin rashes, urticaria, mental depression, breast changes, altered libido, drowsiness/insomnia, hirsutism, alopecia, jaundice and anaphylactoid reactions (rare).
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Drug Interactions
Clearance enhanced by enzyme-inducing drugs. Influence diabetic control of antidiabetic drugs. Avoid St. John's wort.
Potentially Fatal: Cyclosporin (risk of toxicity). |
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Lab Interference
Serum lipid profile and liver function tests alterations.
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Action
Description:
Mechanism of Action: Chlormadinone is a progestogen structurally related to progesterone, with some anti-androgenic activity. It is used alone or combined with an estrogen in the treatment of menstrual disorders. It has also been used in some countries in the management of prostate cancer. |
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