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Indications and Dosage
Topical/Cutaneous
Mycosis fungoides Adult: Apply a thin film once daily to the affected area.
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Special Precautions
Pregnancy and lactation.
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Adverse Reactions
Immune system disorders: Hypersensitivity.
Skin and subcutaneous tissue disorders: Dermatitis, skin infections, pruritus, skin ulceration, skin blister, hyperpigmentation. |
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Intracavitary/IV/Parenteral/Topical: D
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Patient Counseling Information
Avoid any contact with mucous membranes.
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Monitoring Parameters
Monitor for hypersensitivity and skin reactions.
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Action
Description:
Mechanism of Action: Chlormethine is a bifunctional alkylating agent that inhibits rapidly proliferating cells. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 4033, Mechlorethamine. https://pubchem.ncbi.nlm.nih.gov/compound/Mechlorethamine. Accessed Sept. 24, 2020. |
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Storage
Unopened tubes: Store between -15 to - 25°C. After defrosting: Store between 2-8°C.
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MIMS Class
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ATC Classification
L01AA05 - chlormethine ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.
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References
Buckingham R (ed). Chlormethine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 29/06/2020. Joint Formulary Committee. Chlormethine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 29/06/2020.
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