Reduction of elevated total and LDL-C levels in patients w/ primary hypercholesterolemia when response to diet and other non-pharmacological measures has been inadequate. Reduction of elevated cholesterol levels in patient w/ combined hypercholesterolemia & hypertriglyceridemia when hypercholesterolemia is the abnormality of more concern.
Dosage/Direction for Use
Adult Initially 20 mg/day. Dose range: 20-80 mg/day in single or divided doses. Max: 80 mg/day. Patient taking immunosuppressants 10 mg/day. Max: 20 mg/day.
Administration
Should be taken with food.
Contraindications
Active liver disease or persistent elevations of serum transaminases. Pregnancy & lactation.
Special Precautions
Patients who are alcoholics or have past history of liver disease. Perform liver function test during therapy. Rhabdomyolysis patients w/ or w/o renal dysfunction on concomitant use of erythromycin. Prepubertal patients & childn.
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