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Indications and Dosage
Topical/Cutaneous
Seborrhoeic dermatitis Adult: As 1% ciclopirox base shampoo: Apply 5-10 mL unto the scalp twice weekly for 4 weeks, with a Min of 3 days between application. Topical/Cutaneous Skin fungal infections Adult: As 0.77% (ciclopirox base) cream/gel/suspension/solution: Apply onto affected areas bid. Topical/Cutaneous Nail fungal infections Adult: As 8% (ciclopirox base) lacquer: Apply onto the affected nails once daily.
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Contraindications
Hypersensitivity; occlusive wrappings/dressings.
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Special Precautions
Children <10 yr; pregnancy, lactation. Avoid contact with eyes. For external use only.
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Adverse Reactions
Pruritus, burning sensation; headache, rash, irritation, dryness.
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Topical: B
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Action
Description:
Mechanism of Action: Ciclopirox has a wide spectrum of antifungal activity and some antibacterial activity. Inhibits most Candida, Epidermophyton, Microsporum, Trichophyton species and M. furfur by inhibiting transport of essential elements in fungal cells, thus disrupting DNA, RNA and protein synthesis. Pharmacokinetics: Absorption: <2% through intact skin (topical). Distribution: To epidermis, corium (dermis), including hair, hair follicles and sebaceous glands. Protein-binding: 94-98%. Excretion: Urine, faeces (small amounts). Elimination half-life: 1.7 hr (solution); 5.5 hr (gel). |
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Storage
Store between 15-30°C.
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MIMS Class
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