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Indications and Dosage
Oral
Gastrointestinal tract spasm Adult: 50 mg bid-tid. May also be given via rectal suppository.
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Contraindications
Prostatic enlargement, paralytic ileus or pyloric stenosis.
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Special Precautions
Caution when used in patients with diarrhoea or fever. Thyrotoxicosis, heart failure and in cardiac surgery. Children, elderly. Not advisable for use in angle-closure glaucoma.
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Adverse Reactions
Mouth dryness, reduced bronchial secretions, pupil dilatation with loss of accommodation and photophobia. Skin flushing and dryness, transient bradycardia followed by tachycardia, with palpitations and arrhythmias, and micturition difficulty, as well as reduction in tone and motility of the GI tract resulting in constipation.
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Drug Interactions
Effects may be enhanced when used with drugs with antimuscarinic properties e.g. amantadine, some antihistamines, phenothiazines and TCAs. May antagonise the GI effects of cisapride, domperidone and metoclopramide.
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Action
Description:
Mechanism of Action: Cimetropium bromide is a quaternary ammonium antimuscarinic. It has been used as an antispasmodic in the treatment of GI disorders |
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MIMS Class
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