|
Indications and Dosage
Oral
Urinary tract infections Adult: Treatment: 500 mg bid. Prophylaxis: 500 mg daily at bedtime as a single dose.
|
|
Renal Impairment
Avoid use or use in reduced dose.
|
|
Administration
May be taken with or without food. Take consistently w/ or w/o meals.
|
|
Contraindications
Hypersensitivity; severe renal impairment; pregnancy, lactation; babies <3 mth, child, adolescent; convulsive conditions.
|
|
Special Precautions
G6PD deficiency; impaired renal or hepatic function; exposure to strong sunlight; porphyria. Monitor blood counts, renal and hepatic function if treatment is >2 wk Arthralgia (discontinue).
|
|
Adverse Reactions
Hypersensitivity reactions; nausea, vomiting, diarrhoea; abdominal pain; neurological effects; toxic psychoses or convulsions; skin reactions; tendon damage; hepatic effects.
Potentially Fatal: Auto-immune haemolytic anaemia (elderly). |
|
Drug Interactions
Probenecid, ciclosporin, oral anticoagulants, NSAIDS, xanthines; nitrofurantoin.
Potentially Fatal: High-dose IV melphalan in child. |
|
Lab Interference
False-positive results in urinary glucose tests using copper reduction method.
|
|
Action
Description:
Mechanism of Action: Cinoxacin inhibits DNA gyrase activity thus interfering with bacterial DNA replication. It is active against gram-negative bacteria, Pseudomonas aeruginosa, gram-positive bacteria and anaerobes are not susceptible. Pharmacokinetics: Absorption: Rapidly and almost completely absorbed after oral admin. Distribution: >60% bound to plasma proteins. Metabolism: Metabolised hepatically. Excretion: Renally excreted; >95% of a dose is recovered in the urine within 24 hr. |
|
MIMS Class
|
Sign Out
