Nausea and vomiting, Prokinetic agent
Adult: As malate: 500 mcg tid.
Child: As malate: 15-20 mcg/kg tid.
Child: As malate: 15-20 mcg/kg tid.
Parenteral
Nausea and vomiting, Prokinetic agent
Adult: For acute symptoms: As malate: IV/IM: 0.5-1 mg.
Indications and Dosage
Oral
Nausea and vomiting, Prokinetic agent Adult: As malate: 500 mcg tid. Child: As malate: 15-20 mcg/kg tid. Parenteral Nausea and vomiting, Prokinetic agent Adult: For acute symptoms: As malate: IV/IM: 0.5-1 mg.
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Administration
Should be taken on an empty stomach. Take 30 min before meals.
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Contraindications
GI haemorrhage, obstruction, perforation or immediately after surgery. Patients with pheochromocytoma.
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Special Precautions
Impaired renal function, epilepsy, Parkinson's disease; history of depression. May impair ability to drive or operate machinery. Children, young patients, elderly.
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Adverse Reactions
Extrapyramidal symptoms; restlessness, drowsiness, diarrhoea; hypotension, hypertension, dizziness, headache, depression; galactorrhoea.
Potentially Fatal: Neuroleptic malignant syndrome. |
Drug Interactions
Other centrally active drugs and those with extrapyramidal effects. Increased toxicity with lithium. Antagonism of GI effects with antimuscarinics and opioid analgesics. May affect absorption of other drugs.
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Lab Interference
Transient increased in plasma-aldosterone concentration.
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Action
Description:
Mechanism of Action: Clebopride is a substituted benzamide with prokinetic and antiemetic properties. |