Clindamycin + Benzoyl peroxide

Topical/Cutaneous
Acne vulgaris

Hypersensitivity to clindamycin, lincomycin, or benzoyl peroxide. History of regional enteritis, ulcerative colitis, pseudomembranous or antibiotic-associated colitis.

Atopic patients.

Significant: Anaphylaxis, allergic reaction.
Dermatologic: Erythema, peeling, burning sensation, dryness, desquamation, itching, irritation, stinging, discolouration, exfoliation, contact dermatitis, rash, urticaria.
Potentially Fatal: Clostridium difficile-associated colitis manifested by severe persistent diarrhoea, severe abdominal cramps, stool w/ blood and mucous.

Topical: C

Avoid unnecessary sun exposure. May cause discolouration of hair and dyed fabrics.

Symptom: Severe irritation. Management: Symptomatic treatment.

Clindamycin is antagonised by erythromycin. Clindamycin may enhance the action of other neuromuscular blocking agents. Benzoyl peroxide may cause temporary discolouration of skin and facial hair w/ topical sulfone preparations. May cause cumulative irritation or dermatitis w/ other topical acne preparations (e.g. tretinoin, isotretinoin, tazarotene).

Description:
Mechanism of Action: Clindamycin is a semisynthetic lincosamide which is mainly bacteriostatic but may also be bactericidal depending on drug concentration, infection site, and organism. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunits, thereby blocking the peptide bond formation of susceptible organisms. Benzoyl peroxide has mild keratolytic effect and an antimicrobial activity which is attributed to its oxidising effect. Both are active against Propionibacterium acnes, an organism associated w/ acne vulgaris.
Pharmacokinetics:
Absorption: Clindamycin: Minimal absorption (approx 4-5%) through the skin. Benzoyl peroxide: Approx 5% is absorbed through the skin.
Metabolism: Benzoyl peroxide: Metabolised in the skin to benzoic acid.
Excretion: Benzoyl peroxide: Via urine.

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 446598, Clindamycin. https://pubchem.ncbi.nlm.nih.gov/compound/Clindamycin. Accessed Aug. 16, 2023.

Source: National Center for Biotechnology Information. PubChem Database. Benzoyl peroxide, CID=7187, https://pubchem.ncbi.nlm.nih.gov/compound/Benzoyl-peroxide (accessed on Jan. 21, 2020)

Store below 25°C. Do not freeze.

Acne Treatment Preparations

D10AF51 - clindamycin, combinations ; Belongs to the class of topical antiinfective preparations used in the treatment of acne.

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Joint Formulary Committee. Benzoyl Peroxide with Clindamycin. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/03/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Clindamycin Phosphate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 03/03/2017.