Clobetasol + Neomycin + Nystatin: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Severe inflammatory skin disorders

Adult: As cream/ointment. Each g contains clobetasol propionate 0.5 mg, neomycin sulfate 5 mg and nystatin 100 000 units. Apply a thin layer onto the affected area(s) 1-2 times daily until improvement occurs. Not to be used for >7 days without medical supervision.
Child: >2 yr: As cream/ointment. Each g contains clobetasol propionate 0.5 mg, neomycin sulfate 5 mg and nystatin 100 000 units. Apply a thin layer onto the affected area(s) 1-2 times daily until improvement occurs. Not to be used for >7 days without medical supervision.

Contraindications

Primary cutaneous viral infections, rosacea, acne vulgaris and perioral dermatitis. Neonates and infants.

Special Precautions

Avoid prolonged treatment. Caution when applied to area near to the eyes. Renal impairment, elderly and children. Pregnancy and lactation.

Adverse Reactions

May cause atrophic changes in the skin e.g. skin thinning, striae and dilatation of superficial blood vessels. Pigmentation and hypertrichosis.

Drug Interactions

If there is substantial systemic absorption, neomycin may prolong and intensify respiratory depressant effects of neuromuscular blockers.

Action

Description:
Mechanism of Action: Clobetasol is a highly active corticosteroid that has topical anti-inflammatory action brought about partly by vasoconstriction and reduced collagen synthesis. Neomycin is an aminoglycoside antibiotic that binds to ribosomal 30S and 50S subunits of susceptible bacteria, thus inhibiting protein synthesis; it also causes misreading of the genetic codes on the mRNA template. Nystatin works by binding to ergosterol in the cell membrane of fungus resulting in a change in the cell wall permeability and leakage of cellular components.

Storage

Store below 25°C.

MIMS Class

Psoriasis, Seborrhea & Ichthyosis Preparations

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